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  • FILE – Actress Anne Heche poses for a portrait to...

    FILE – Actress Anne Heche poses for a portrait to promote the film, “The Last Word” during the Sundance Film Festival in Park City, Utah on Jan. 23, 2017. A spokesperson for Heche says the actor is on life support after suffering a brain injury in a fiery crash a week ago and isn’t expected to survive. The statement released on behalf of her family said she is being kept on life support to determine if she is a viable organ donor. (Photo by Taylor Jewell/Invision/AP, File)

  • LOS ANGELES, UNITED STATES: This 19 February 2000 file photo...

    LOS ANGELES, UNITED STATES: This 19 February 2000 file photo shows comedian Ellen DeGeneres (L) and actress Anne Heche 19 February 2000 at the annual Human Rights fundraising dinner in Los Angeles, CA. Heche was reported to have been hospitalized 19 August 2000 in Fresno, California, hours after her breakup with Ellen DeGeneres became public, a sheriff's deputy confirmed 21 August 2000. (ELECTRONIC IMAGE) AFP PHOTO/Jim RUYMEN/FILES (Photo credit should read JIM RUYMEN/AFP via Getty Images)

  • PASADENA, CALIFORNIA - SEPTEMBER 04: Anne Heche attends the 27th...

    Rich Fury/Getty Images archives

    PASADENA, CALIFORNIA - SEPTEMBER 04: Anne Heche attends the 27th Annual Race To Erase MS: Drive-In To Erase MS at Rose Bowl on September 04, 2020 in Pasadena, California. (Photo by Rich Fury/Getty Images for Race to Erase MS)

  • Dustin Hoffman, from left, Anne Heche, center, and Robert DeNiro...

    Dustin Hoffman, from left, Anne Heche, center, and Robert DeNiro starred in the 1998 movie "Wag The Dog." (AP Photo/New Line Cinema)

  • FILE – Anne Heche arrives at the premiere of “The...

    FILE – Anne Heche arrives at the premiere of “The Tender Bar” on Dec. 12, 2021, at the TCL Chinese Theatre in Los Angeles. Heche was in the hospital Saturday, Aug. 6, 2022, following an accident in which her car smashed into a house and flames erupted, a representative for the actor told People magazine. The representative, who was not identified, told the magazine that Heche was in stable condition a day after Friday’s accident. (Photo by Jordan Strauss/Invision/AP, File)

  • Anne Heche

    2002 photograph: Anne Heche when she was preparing to replace Jennifer Jason Leigh in the Broadway production of "Proof." (AP Photo/Jim Cooper)

  • NEW YORK - FEBRUARY 4: (L-R) Actors Anne Heche and...

    NEW YORK - FEBRUARY 4: (L-R) Actors Anne Heche and Alec Baldwin at a photo call for Roundabout Theatre's new play "Twentieth Century" February 4, 2004 in New York City. (Photo by Peter Kramer/Getty Images)

  • NEW YORK, NEW YORK - APRIL 29: actors Anne Heche...

    NEW YORK, NEW YORK - APRIL 29: actors Anne Heche and Alec Baldwin take a bow during curtain call at the "Twentieth Century" Benefit Concert Reading at Studio 54 on April 29, 2019 in New York City. (Photo by Nicholas Hunt/Getty Images)

  • Anne Heche, here in March, was injured in a car...

    Anne Heche, here in March, was injured in a car accident on August 5.

  • Anne Heche attends the Hollywood Reporter and SAG AFRA 2017...

    Anne Heche attends the Hollywood Reporter and SAG AFRA 2017 Emmy Nominees Night party at the Jean-Georges at the Waldorf Astoria in Beverly Hills, on September 14, 2017. / AFP PHOTO / CHRIS DELMASCHRIS DELMAS/AFP/Getty Images

  • Anne Heche as Beth Harper on "Save Me" and as...

    Anne Heche as Beth Harper on "Save Me" and as Patricia Campbell on "The Brave." (r-l, NCB Universal and Jeff Riedel - NBC)

  • Actress Anne Heche attends the Entertainment Weekly and People Magazine...

    Actress Anne Heche attends the Entertainment Weekly and People Magazine New York Upfronts celebration at Second Floor on Monday, May 15, 2017, in New York. (Photo by Evan Agostini/Invision/AP)

  • Actress Anne Heche poses at the premiere of the film...

    Actress Anne Heche poses at the premiere of the film "The Dinner" at the Writers Guild Theater on Monday, May 1, 2017, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP)

  • Actress Anne Heche poses at the premiere of the film...

    Actress Anne Heche poses at the premiere of the film "The Dinner" at the Writers Guild Theater on Monday, May 1, 2017, in Beverly Hills, Calif. (Photo by Chris Pizzello/Invision/AP)

  • Actors Anne Heche, Thomas Sadoski, and AnnJewel Lee Dixon of...

    Actors Anne Heche, Thomas Sadoski, and AnnJewel Lee Dixon of 'The Last Word' (Photo by Rich Polk/Getty Images for IMDb)

  • In this film publicity image released by Fox Searchlight Films,...

    In this film publicity image released by Fox Searchlight Films, Anne Heche, left, and Ed Helms are shown in a scene from "Cedar Rapids." (AP Photo/Fox Searchlight, Zade Rosenthal)

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LOS ANGELES — Anne Heche, the Emmy-winning film and television actor whose dramatic Hollywood rise in the 1990s and accomplished career contrasted with personal chapters of turmoil, died of injuries from a fiery car crash. She was 53.

Heche was “peacefully taken off life support,” spokeswoman Holly Baird said in a statement Sunday night.

Heche had been on life support at a Los Angeles burn center after suffering a “severe anoxic brain injury,” caused by a lack of oxygen, when her car crashed into a home Aug. 5, according to a statement released Thursday by a representative on behalf of her family and friends.

She was declared brain-dead Friday, but was kept on life support in case her organs could be donated, an assessment that took nine days. In the U.S., most organ transplants are done after such a determination.

A native of Ohio whose family moved around the country, Heche endured an abusive and tragic childhood, one that helped push her into acting as a way of escaping her own life. She showed enough early promise to be offered professional work in high school and first came to prominence on the NBC soap opera “Another World” from 1987 to 1991, winning a Daytime Emmy Award for the role of twins Marley and Vicky Hudson, who on the show sustained injuries that anticipated Heche’s: Vicky falls into a coma for months after a car crash.

By the late 1990s Heche was one of the hottest actors in Hollywood, a constant on magazine covers and in big-budget films. In 1997 alone, she played opposite Johnny Depp as his wife in “Donnie Brasco” and Tommy Lee Jones in “Volcano” and was part of the ensemble cast in the original “I Know What You Did Last Summer.”

The following year, she starred with Ford in “Six Days, Seven Nights” and appeared with Vince Vaughn and Joaquin Phoenix in “Return to Paradise.” She also played one of cinema’s most famous murder victims, Marion Crane of “Psycho,” in Gus Van Sant’s remake of the Alfred Hitchcock classic, and co-starred in the indie favorite “Walking and Talking.”

Around the same time, her personal life led to even greater fame, and both personal and professional upheaval. She met Ellen DeGeneres at a the 1997 Vanity Fair Oscar party, fell in love and began a 3-year relationship that made one of Hollywood’s first openly gay couples. But Heche later said her career was damaged by an industry wary of casting her in leading roles. She would remember advisers opposing her decision to have DeGeneres accompany her to the premiere of “Volcano.”

“We were tapped on the shoulder, put into her limo in the third act and told that we couldn’t have pictures of us taken at the press junket,” Heche said in 2018 on the podcast Irish Goodbye.

After she and DeGeneres parted, Heche had a public breakdown and would speak candidly of her mental health struggles.

Heche’s delicately elfin look belied her strength on screen. When she won the National Board of Review’s 1997 best supporting actress award, the board cited the one-two punch of “Donnie Brasco” and the political satire “Wag the Dog,” in which Heche portrayed a cynical White House aide and held her own against film great Robert De Niro.

Heche also called effectively on her apparent fragility. In 2002 she starred on Broadway in the play “Proof” as a woman fearful of losing her sanity just like her father, a brilliant mathematics professor. An Associated Press review praised her “touching performance, vulnerable yet funny, particularly when Catherine mocks the suspicions about her mental stability.”

In the fall of 2000, soon after her break-up with DeGeneres, Heche was hospitalized after knocking on the door of a stranger in a rural area near Fresno, California. Authorities said she had appeared shaken and disoriented and spoke incoherently to the residents.

In a memoir released the following year, “Call Me Crazy,” Heche talked about her lifelong battles. During a 2001 interview with TV journalist Barbara Walters, Heche recounted in painful detail alleged sexual abuse by her father, Donald Heche, who professed to be devoutly religious and died in 1983 from complications of AIDS. Heche described her suffering as so extreme she developed a separate personality and imagined herself descended from another planet.

In the final days of his life, Heche said, she learned he was secretly gay and that she believed his inability to live honestly fueled his anger and hurtful behavior. Not long after her father died, her brother Nathan — one of her four siblings — was killed in a car crash.

“I’m not crazy. But it’s a crazy life. I was raised in a crazy family and it took 31 years to get the crazy out of me,” Heche told Walters. In an effort to escape the past, “I drank. I smoked. I did drugs. I had sex with people. I did anything I could to get the shame out of my life.”

Heche dated Steve Martin in the 1990s, and is widely believed to have inspired the childlike, but ambitious aspiring actor played by Heather Graham in his Hollywood spoof “Bowfinger.” She later had a son with camera operator Coleman Laffoon, to whom she was married from 2001 to 2009. She had another son during a relationship with actor James Tupper, her co-star on the TV series “Men In Trees.”

Heche worked consistently in smaller films, on Broadway and on TV shows in the past two decades. She recently had recurring roles on the network series “Chicago P.D.” and “All Rise,” and in 2020 was a contestant on “Dancing With the Stars.”